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Tissue for HPV research was not on most patients, but one of the oropharynx patients who were tested, 75% were p16 positive. Burtness and colleagues concluded the first clinical trial investigating the role of cetuximab in the first line treatment of incurable advanced SCCHN. An overall total of 117 patients who'd not received prior chemotherapy for chronic andor metastatic disease were randomized to either cisplatin with placebo or to cisplatin with cetuximab. 2 months. But, the difference in survival was not statistically significant, likely because of insufficient power, along with a study design that helped crossover to cetuximab if individuals had progressed to the placebo arm. In a much bigger phase III research known as the SERIOUS PF04620110 demo, 442 people with advanced SCCHN who had not received prior treatment for recurrentmetastatic infection were randomized to whether jewelry containing doublet or even a similar doublet with cetuximab. The chemotherapy regimen used was platinum in conjunction with 5 fluorouracil. Patients randomized to receive cetuximab with chemotherapy may continue to receive maintenance cetuximab until advancement. Cross to cetuximab for all those patients initially randomized to chemotherapy alone wasn't authorized. The addition of cetuximab demonstrated a statistically significant improvement in survival from 7. 4 to 10. 1 weeks. These data established the role of cetuximab in first line therapy for advanced SCCHN. Three tests have established the game of cetuximab among patients with platinum refractory disease. The response rate was 10%, using a disease control rate of 53%, median time to progression of 2. 79 months and overall survival of 6. 01 months. The response rates were 6% for the PD2 cohort with median survivals of 11, 20% for the PD1 cohort and 18% for the SD cohort. 7 months, 6. 1 months and 4. 3 weeks respectively. A third phase-ii study enrolled 103 patients actively failing platinum-based therapies and handled them with cetuximab as a monotherapy. They reported a reply rate of 12. 6%, median overall survival of 5 and disease control rate of 46%. eighty-four months.